Neuronal autophagy and neurodegenerative diseases
نویسندگان
چکیده
منابع مشابه
Neuronal Mitophagy in Neurodegenerative Diseases
Neuronal homeostasis depends on the proper functioning of different quality control systems. All intracellular components are subjected to continuous turnover through the coordinated synthesis, degradation and recycling of their constituent elements. Autophagy is the catabolic mechanism by which intracellular cytosolic components, including proteins, organelles, aggregates and any other intrace...
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The growing range of implications of autophagy in a myriad of human physiological and pathological conditions has witnessed an exponential increase in the number of studies published over the last decade. The role of autophagy to function predominantly as a cellular survival mechanism has been widely accepted over the last few years. It is an evolutionarily conserved protein degradation pathway...
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Autophagy, a catabolic process necessary for the maintenance of intracellular homeostasis, has recently been the focus of numerous human diseases and conditions, such as aging, cancer, development, immunity, longevity, and neurodegeneration. However, the continued presence of autophagy is essential for cell survival and dysfunctional autophagy is thought to speed up the progression of neurodege...
متن کاملThe Function of Autophagy in Neurodegenerative Diseases
Macroautophagy, hereafter referred to as autophagy, is a bulk degradation process performed by lysosomes in which aggregated and altered proteins as well as dysfunctional organelles are decomposed. Autophagy is a basic cellular process that maintains homeostasis and is crucial for postmitotic neurons. Thus, impaired autophagic processes in neurons lead to improper homeostasis and neurodegenerat...
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ژورنال
عنوان ژورنال: Experimental & Molecular Medicine
سال: 2012
ISSN: 1226-3613,2092-6413
DOI: 10.3858/emm.2012.44.2.031